Home Drugs Atripla – Generic Name, Combination, Uses, Side Effects and Dosage

Atripla – Generic Name, Combination, Uses, Side Effects and Dosage

Atripla is a medication prescribed for the treatment of Human Immunodeficiency Virus (HIV) in adults and children who weigh at least 88 pounds or 40kg. It is a combination of three antiretroviral drugs, namely efavirenz, emtricitabine, and tenofovir.

Atripla has a boxed warning from the Food and Drug Administration (FDA) as it has the potential to worsen Hepatitis B virus infection in people with HIV.

Generic name: efavirenz, emtricitabine, and tenofovir
Brand name: Atripla


Atripla Uses

It is used alone or in combination with other antiretroviral medications to treat HIV in adults and children who weigh at least 88 pounds or 40kg.

How To Take Atripla

Follow your doctor’s instructions for taking Atripla. Read all drug guides or instruction sheets and follow all guidelines on your prescription label. Take this drug with a full glass of water on an empty stomach. Medical testing will be required on a regular basis.

This medicine may interfere with a drug-screening urine test, causing erroneous results. Inform the lab personnel that you are taking efavirenz, emtricitabine, and tenofovir.

Atripla should be kept at room temperature, free from moisture, heat, and light, in its original container. When not in use, keep the bottle tightly closed.

If you’ve ever had hepatitis B, it’s possible that the virus will reactivate or worsen in the months after you stop using Atripla. You may need liver function tests on a regular basis while taking this medication and for several months after you stop taking it.


Atripla is a combination of three antiretroviral drugs, 600 mg of efavirenz (EFV), 200 mg of emtricitabine (FTC), and 300 mg of tenofovir disoproxil fumarate (TDF). The recommended dosage in adults and pediatric patients weighing at least 40 kg is one tablet once daily taken orally on an empty stomach. Dosing at bedtime may improve the tolerability of nervous system symptoms

Side Effects

The following side effects can be associated with taking Atripla. They include mild and severe side effects.

Consult your doctor or pharmacist for further information on any potential adverse effects. They can provide you with advice on how to deal with any unpleasant side effects.

Common mild side effects include:

Severe side effects include:

  • severe worsening of hepatitis B (HBV).
  • liver damage
  • mood changes
  • hallucinations
  • kidney injury
  • bone pain
  • bone fractures
  • convulsions
  • Immune Reconstitution Inflammatory Syndrome (IRIS)
  • fat build up in body parts including the torso and behind the shoulders
  • weight loss in face and limbs

Severe side effects are uncommon, but they can happen. If you experience any major side effects, contact your doctor at once. If your symptoms are life-threatening or you believe you’re having a medical emergency, dial 911 or your local emergency number.


Atripla should not be taken with adefovir, atazanavir, voriconazole, emtricitabine, lamivudine, or tenofovir-containing drugs.

Inform your doctor about all of your existing medications, as well as any that you begin or stop taking. Many medications interact with one another, and some medications should never be taken together.

Atripla has the potential to induce serious or deadly liver damage. If you develop abdominal pain or swelling, a loss of appetite, dark urine, or yellowing of your skin or eyes, call your doctor right away.

Lactic acidosis, a severe build-up of lactic acid in your blood, is a significant side effect of Atripla. If you have unusual muscle pain, difficulties breathing, stomach pain, dizziness, feeling cold, or feeling very weak or exhausted, call your doctor or get emergency medical treatment.

If you’ve ever had hepatitis B, it could reactivate or worsen if you stop taking Atripla. For several months, you may require repeated liver function testing.

Atripla Tablets Price

The average retail price for 30 Atripla oral tablets is about $3,136. The cost may be much lower depending on your insurance plan.

There are also Patient assistance programs (PAPs) available to low-income or uninsured and under-insured people who meet specific guidelines. These programs offer medications at discounted prices.

PAPs for Atripla include:

Atripla Alternatives

As a general rule, patients with HIV must take more than one medication. Because of this, there are a wide variety of HIV treatments that combine two or more drugs.  Emtricitabine, tenofovir disoproxil fumarate, and efavirenz are the active ingredients of Atripla.

Other HIV treatment alternatives include the following:

  • Triumeq (abacavir, dolutegravir, and lamivudine)
  • Genvoya (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide)
  • Stribild (elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate)
  • Descovy (emtricitabine and tenofovir alafenamide)
  • Symtuza (darunavir, cobicistat, emtricitabine, and tenofovir alafenamide)
  • Truvada (emtricitabine and tenofovir disoproxil fumarate)
  • Complera (emtricitabine, rilpivirine, and tenofovir disoproxil fumarate)
  • Juluca (dolutegravir and rilpivirine)
  • Biktarvy (bictegravir, emtricitabine, and tenofovir alafenamide)
  • Odefsey (emtricitabine, rilpivirine, and tenofovir alafenamide)


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