Home Drugs Asacol HD – Drug Uses, Side Effects and Precautions

Asacol HD – Drug Uses, Side Effects and Precautions

Asacol HD (mesalamine) is an FDA-approved medication used for the treatment of ulcerative colitis – an inflammatory bowel disease characterized by ulceration of the lining of the large intestine and rectum.

The active ingredient in Asacol HD is mesalamine belongs to the class of drugs called aminosalicylates.

Generic name: mesalamine
Brand name: Asacol HD

Asacol HD

Uses of Asacol HD

It is taken orally as delayed-release tablets to treat moderately active ulcerative colitis in adults.

How To Take Asacol HD

Asacol HD should be taken exactly as directed by your doctor. Read all drug guides or instruction sheets and follow all guidelines on your prescription label.

Certain medical tests may be affected by this medication. Let your doctor be aware of all the medications you are taking.

Asacol HD should be taken on an empty stomach, at least 1 hour before or after a meal. To avoid kidney stones, drink plenty of water. Do not crush, chew, or break the tablet; instead, swallow it whole. If you have difficulties swallowing the tablet, tell your doctor.

If you notice undissolved tablets in your feces, contact your doctor. If your ulcerative colitis symptoms do not improve or worsen, see your doctor.

Certain medical tests may be affected by this medication. Any doctor who treats you should be aware that you are taking this medication. Blood tests to assess your blood cells or kidney function may be required on a regular basis.

Keep away from moisture and heat. Store at room temperature.

Side Effects of Asacol

The following side effects can be associated with taking Asacol HD. They include mild and severe side effects.

Consult your doctor or pharmacist for further information on any potential adverse effects. They can provide you with advice on how to deal with any unpleasant side effects.

Mild side effects include:

Severe side effects include:

  • Mesalamine-induced acute intolerance syndrome
  • Kidney stones
  • Kidney disease
  • Allergic reaction

Severe side effects are uncommon, but they can happen. If you experience any major side effects, contact your doctor at once. If your symptoms are life-threatening or you believe you’re having a medical emergency, dial 911 or your local emergency number.


If you get severe stomach discomfort, stomach cramps, or bloody diarrhea, stop taking Asacol HD and notify your doctor right away.


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