Home A-E Apokyn – Drug Uses, Side Effects and Precautions

Apokyn – Drug Uses, Side Effects and Precautions

Apokyn is an FDA-approved prescription medication used to treat the off-episodes of advanced Parkinson’s disease (PD) in adults. It contains an active called apomorphine hydrochloride which belongs to the class of drugs called non-ergoline dopamine agonists.

Generic name: apomorphine injection
Brand name: Apokyn
Drug class: Dopaminergic anti parkinsonism agents


Uses of Apokyn

It is used in combination with other drugs to treat the off-episodes of advanced Parkinson’s disease (PD) in adults.

How To Use Apokyn

Take Apokyn exactly as directed by your doctor. Read all drug guides or instruction sheets and follow all guidelines on your prescription label. Your doctor may adjust your dose from time to time.

Apokyn injections are given beneath the skin. Your initial dose will be given by a healthcare provider, who may also instruct you on how to use the drug appropriately on your own. Apokyn should not be injected into a vein.

Any instructions for use that came with your medicine should be read and followed carefully. If you don’t understand something, go to your doctor or pharmacist.

Only prepare an injection when you’re ready to administer it. If the drug is hazy, has changed color, or has particles in it, do not use it. For new medication, contact your pharmacist.

It’s critical to accurately measure your Apokyn injection dose. An apomorphine injection pen’s dose is measured in milliliters (mL), which are marked on the pen. Your prescribed dose, on the other hand, could be in milligrams (mg). A milligram of apomorphine, or 1 mg, is equal to 0.1 mL on the injectable pen.

Your healthcare practitioner will show you where to inject Apokyn into your body. Each time you deliver an injection, use a different location. Do not repeat injections in the same location.

Other drugs may be prescribed to assist you avoid nausea and vomiting. Only take the anti-nausea medication that your doctor has prescribed. Some anti-nausea medications can exacerbate apomorphine’s adverse effects or worsen your Parkinson’s symptoms. Your blood pressure will need to be monitored on a regular basis.

If the drug in an Apokyn injection pen gets into your eyes or on your skin, it might cause irritation. Rinse with water if this happens.

If you suddenly stop using Apokyn, you may have unpleasant withdrawal symptoms such as fever and confusion. Inquire with your doctor about how to safely discontinue taking this medication.

Ask your doctor before restarting Apokyn injection if you haven’t used it in 7 days or longer. It’s possible that you’ll need to start over with a lower dose.

Store away from moisture and heat at room temperature. Only use a needle and syringe once before storing them in a puncture-resistant “sharps” container. Follow your state’s or municipality’s regulations for how to dispose of this container. Keep it out of children’s and pets’ reach.

Side Effects

The following side effects can be associated with taking Apokyn. They include mild and severe side effects.

Consult your doctor or pharmacist for further information on any potential adverse effects. They can provide you with advice on how to deal with any unpleasant side effects.

Mild side effects include:

Severe side effects include:

  • torsades de pointes
  • hallucinations
  • pleural effusion
  • increased sexual urges
  • priapism
  • allergic reaction
  • low blood pressure
  • severe nausea and vomiting

Severe side effects are uncommon, but they can happen. If you experience any major side effects, contact your doctor at once. If your symptoms are life-threatening or you believe you’re having a medical emergency, dial 911 or your local emergency number.


When Apokyn is used with other medications, serious drug interactions might occur. Let your doctor know all the drugs you’re taking, as well as any new or discontinued medications.

If you’re taking alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran), or palonosetron, you shouldn’t take Apokyn (Aloxi).

If you have an electrolyte imbalance (such as low potassium or magnesium levels in your blood), a slow heart rate, low blood pressure, or dizzy spells, a history of “Long QT syndrome,” a history of stroke or heart attack, asthma, sulfite allergy, or liver or kidney disease, tell your doctor before taking Apokyn.

While using this medicine, you may experience increased sexual desires, unexpected gambling desires, or other strong desires. If you develop any extreme or unexpected cravings while taking Apokyn, talk to your doctor.


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