Home Drugs Aplenzin – Drug Uses, Side Effects and Precautions

Aplenzin – Drug Uses, Side Effects and Precautions

Aplenzin is an FDA-approved prescription medication used to treat major depressive disorder and seasonal affective disorder in adults. It contains bupropion hydrobromide which belongs to the aminoketone drug class.

Aplenzin has a boxed warning from the Food and Drug Administration (FDA) as it can cause patients to have have suicidal thoughts and behaviors.

Generic name: bupropion hydrobromide extended-release tablets
Brand name: Aplenzin


Uses of Aplenzin

It’s used in adults to:

How To Take Aplenzin

It should be taken exactly as directed by your doctor. This medicine should not be taken in bigger or lower doses or for longer than indicated. If you take too much of this medication, you run the chance of having a seizure.

An Aplenzin extended-release tablet should not be crushed, chewed, or broken. Completely dissolve the tablet in your mouth.

Unless you suffer a seizure while using Aplenzin, you should not adjust your dose or discontinue using it quickly. Sudden stopping can result in unpleasant withdrawal symptoms.

If you suddenly stop using Aplenzin, you can experience unpleasant withdrawal symptoms. Inquire with your doctor about the best way to discontinue taking bupropion without harming yourself.

Some Aplenzin users have experienced severe elevated blood pressure, particularly when using a nicotine replacement therapy (patch or gum). It’s possible that your blood pressure will need to be tested before and during bupropion medication.
This medication may result in a false positive drug test. If you’re giving a urine sample for drug testing, let the lab know you’re taking bupropion.

Keep it away from moisture and heat at room temperature.

Side Effects

The following side effects can be associated with taking Aplenzin. They include mild and severe side effects.

Consult your doctor or pharmacist for further information on any potential adverse effects. They can provide you with advice on how to deal with any unpleasant side effects.

Mild side effects include:

Severe side effects include:

  • Suicidal thoughts and behaviors
  • Unusual thoughts or behaviors
  • Seizures
  • High blood pressure
  • Narrow-angle glaucoma

Severe side effects are uncommon, but they can happen. If you experience any major side effects, contact your doctor at once. If your symptoms are life-threatening or you believe you’re having a medical emergency, dial 911 or your local emergency number.


Do not take Aplenzin if you have seizures, an eating disorder, just quit using alcohol, seizure medication, or sedatives. If you’re taking Aplenzin for depression, don’t try to quit smoking with Zyban.

If you’ve taken an MAO inhibitor in the last 14 days, don’t take bupropion. It’s possible that a harmful drug interaction will occur. Isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine are other examples of MAO inhibitors.

Aplenzin can trigger seizures in some people, especially those with specific medical problems or who are taking certain medications. Tell your doctor about all of your medical issues, as well as any medications you’re taking.

When using an antidepressant for the first time, some young people suffer suicidal thoughts. During your treatment with Aplenzin, your doctor will need to monitor your progress at regular visits. Changes in your mood or symptoms should also be noticed by your family or other carers.

Mood or behavior changes, anxiety, panic attacks, difficulties sleeping, or if you feel impulsive, impatient, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or harming yourself should all be reported to your doctor.


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