Home Drugs Aduhelm – Drug Uses, Side Effects and Precautions

Aduhelm – Drug Uses, Side Effects and Precautions

Aduhelm

Aduhelm is an FDA-approved medication for treating mild cognitive impairment or mild dementia. It is used to treat adults with Alzheimer’s disease. It contains an active ingredient called aducanumab-avwa, which is a monoclonal antibody.

Other inactive ingredients are L-arginine hydrochloride, L-histidine, L-histidine hydrochloride monohydrate, L-methionine, polysorbate 80, and water for injection.

Generic Name: aducanumab-avwa
Dosage Form: injection, for intravenous use

Uses

Aduhelm is used for adults with Alzheimer’s disease. It  should be initiated in patients with mild cognitive impairment or mild dementia stage of disease

How To Take Aduhelm

  • Aduhelm is given through a needle placed in your vein (intravenous (IV) infusion) in your arm.
  • Aduhelm is given every 4 weeks. Each infusion will last about 1 hour

Side Effects

The following side effects can be associated with taking Aduhelm. They include mild and severe side effects.

Consult your doctor or pharmacist for further information on Aduhelm’s potential adverse effects. They can provide you with advice on how to deal with any unpleasant side effects.

Mild side effects include:

Severe side effects include:

  • allergic reaction
  • swelling or bleeding in the brain
  • falls

Severe side effects are uncommon, but they can happen. If you experience any major side effects, contact your doctor at once. If your symptoms are life-threatening or you believe you’re having a medical emergency, dial 911 or your local emergency number.

Precautions

Amyloid Related Imaging Abnormalities (ARIA) is a common side effect of Aduhelm that often goes unnoticed but can be dangerous. The most clinical manifestation is transient swelling in some parts of the brain, which normally goes away with time. With the swelling, some people may experience small areas of bleeding in or on the surface of the brain. Although most people with brain swelling have no symptoms, some people may experience symptoms such as:

Before and during your treatment, your healthcare professional will perform magnetic resonance imaging (MRI) scans to check for ARIA.
If you have any of the symptoms indicated above, contact your healthcare provider or go to the local hospital emergency department immediately.

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